Beta-Thromboglobulin During Normal Pregnancy, LABOR, and Puerperium1

Roberto Romero; Edward Snyder; David Scott; Enrique Oyarzun; John C. Hobbins; Thomas P. Duffy

doi:10.1055/s-2007-999667

American Journal of Perinatology, Table of Contents

Am J Perinatol 1988; 5(2): 109-112
DOI: 10.1055/s-2007-999667

ORIGINAL ARTICLE

Beta-Thromboglobulin During Normal Pregnancy, LABOR, and Puerperium¹

Roberto Romero, Edward Snyder, David Scott, Enrique Oyarzun, John C. Hobbins, Thomas P. Duffy

Departments of Obstetrics and Gynecology, Pediatrics, and Internal Medicine, Yale University School of Medicine, and the Division of Hematology-Oncology of the Department of Medicine, Connecticut School of Medicine, New Haven, Connecticut

1Supported in part by a grant from the Anne and Philip Scharf Foundation for Medical Research. Dr. Romero is the recipient of a Physician Scientist Award from the National Institutes of Health

Abstract

ABSTRACT

Platelet activation has been implicated in the pathogenesis of several obstetrical conditions such as preeclampsia and intrauterine growth retardation. Plasma beta-thromboglobulin (BTG) concentration is an index of in vivo platelet activation. The purpose of this study was to establish normal values of plasma BTG during pregnancy, labor and puerperium. Plasma BTG concentrations were determined from 121 uncomplicated pregnant women, 20 women in labor, 20 puerperal women, and a control group of 28 healthy non-pregnant volunteers. There was no significant difference in plasma BTG concentrations between non-pregnant and pregnant women. Gestational age, labor, and puerperium did not affect plasma BTG concentrations.

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